Heterocyclic Aromatic Amine [HCA] Intake and Prostate Cancer Risk: Effect Modification by Genetic Variants
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چکیده
منابع مشابه
Heterocyclic aromatic amine [HCA] intake and prostate cancer risk: effect modification by genetic variants.
The association between heterocyclic aromatic amine (HCA) intake and prostate cancer (PCa) risk may be modified by genetic variation in enzymes involved in HCA metabolism. We examined this question in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition Heidelberg cohort. The study included 204 PCa cases and 360 matched controls. At baseline, parti...
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We recently reported that heterocyclic amines (HCA) are associated with prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We now use extensive genetic data from this resource to determine if risks associated with dietary HCAs {2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP); 2-amino-3,8-dimethylimidazo[4,5-b]quinoxaline (MeIQx); and 2-amino-3,4,8...
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High intake of meat, particularly red and processed meat, has been associated with an increased risk of a number of common cancers such as breast, colorectum, and prostate in many epidemiological studies. Heterocyclic amines (HCAs) are a group of mutagenic compounds found in cooked meats, particularly well-done meats. HCAs are some of most potent mutagens detected using the Ames/salmonella test...
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BACKGROUND Heterocyclic aromatic amines (HCAs), which arise from cooking meat and fish at high temperatures, may increase the risk of colorectal adenomas. Conversely, flavonoids might counteract the negative effects of HCAs. OBJECTIVE The association between dietary HCA intake and colorectal adenoma incidence was investigated in a prospective cohort study. DESIGN At recruitment (1994-1998),...
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BACKGROUND Increased oxidative stress has been linked to prostate cancer. We investigated oxidative stress-related genetic variants in relation to advanced prostate cancer risk and examined potential interactions with pro- and antioxidant exposures. METHODS A case-cohort analysis was conducted in the prospective Netherlands Cohort Study, which included 58,279 men ages 55 to 69 years. Cohort m...
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ژورنال
عنوان ژورنال: Nutrition and Cancer
سال: 2012
ISSN: 0163-5581,1532-7914
DOI: 10.1080/01635581.2012.678548